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Friday, August 29, 2008

 

Cancer Institute Receives Grant to Study Long-term Health Effects of Traumatic Brain Injuries

John Wayne Cancer Institute Receives Grant to Study Long-term Health Effects of Traumatic Brain Injuries

Research Will Focus on Relationship of Concussion, Pituitary Hormonal Failure and Quality of Life in Retired National Football League Players

SANTA MONICA, Calif.-- July 02, 2008--The John Wayne Cancer Institute at Saint John's Health Center announced today that it has received a grant from the National Operating Committee on Standards for Athletic Equipment to study pituitary hormonal failure (hypopituitarism) in retired football players.

The research, which will be conducted in collaboration with the University of North Carolina's (UNC) Department of Exercise and Sport Science, and the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, will be directed by Daniel F. Kelly, MD, director of the Neuro-Endocrine Tumor Center at the John Wayne Cancer Institute, and Kevin M. Guskiewicz, PhD, chairman of the Department of Exercise and Sport Science at UNC.

In a cohort of retired National Football League (NFL) players, the study will examine the relationship between the number of concussions sustained in players' NFL careers, and their subsequent pituitary hormonal function and post-retirement quality of life. The investigators hypothesize that players sustaining multiple concussions are at increased risk of developing pituitary hormonal dysfunction which may in turn contribute to problems of obesity, fatigue, impaired metabolism, depression, sexual dysfunction and a general poor quality of life.

According to Dr. Kelly, the new study will focus on a relatively unexplored area of traumatic brain injury (TBI)-the potential correlation between recurrent concussions and pituitary hormonal dysfunction. More than 1.2 million Americans sustain a TBI annually, the majority of which are cerebral concussions. Repeat concussions have been shown to be a risk factor for neurodegenerative dementing disorders, including mild cognitive impairment and Alzheimer's Disease. However, little is known about the impact of single or multiple concussions on hormonal function and quality of life. Only in the sport of boxing, have a few small studies shown that boxers are at increased risk of developing pituitary failure. In contrast, it is well known that a single severe head injury can lead to pituitary damage and hormonal abnormalities in up to one third of individuals.

The pituitary is a small bean-shaped gland located immediately below the brain and behind the nasal cavity in the skull base; it is connected to the brain by the thin delicate vascular pituitary stalk. Weighing less than one gram, the pituitary is often called the "master gland" since it controls the secretion of the body's hormones. These essential substances when released by the pituitary into the blood stream have a broad range of effects on growth and development, sexuality and reproductive function, metabolism, the response to stress and overall quality of life.

"This research is long overdue," Dr. Kelly said. "Millions of young people and professional athletes participate in sports that put them at risk of concussion; not just football, but also hockey, rugby, soccer, baseball and basketball. We need to know more about how these so-called "minor head injuries" impact their lives in subsequent years, and in particular, whether multiple concussions can lead to pituitary hormonal failure and poor quality of life."

Using the database of the Center for the Study of Retired Athletes at University of North Carolina and in cooperation with the National Football League Players' Association, 90 study participants will be categorized based on the number of concussions they sustained during their NFL career. The retired players will then be assessed utilizing pituitary hormonal blood tests, body composition testing and neurobehavioral, quality of life and sexual function surveys. Retirees found to be deficient in any hormones such as thyroid, testosterone or growth hormone will be treated with physiological replacement doses of the appropriate hormone and will then have repeat quality of life testing. Hormonal testing assays will be conducted by the General Clinical Research Center at Harbor-UCLA Medical Center under the direction of Professor Christina Wang, an endocrinologist and a study co-investigator.

"The problem of sports-related concussions is increasingly recognized as a major contributor to long-term disability in many retired athletes," said Bob Klein, vice president at Saint John's Health Center and a ten-year NFL veteran with the Los Angeles Rams and San Diego Chargers. "However, the potential impact of concussions on quality of life is not well understood. This research will fill that gap in our knowledge. I have spoken with many of my former colleagues in the NFL, and they share my belief in the critical importance of this study."

The Neuro-Endocrine Tumor Center (www.neuro-endo.org) is housed at Saint John's Health Center and the John Wayne Cancer Institute in Santa Monica, California. The Center's focus of activities is the treatment of pituitary tumors, brain tumors, and other neuro-endocrine disorders including pituitary hormonal deficiencies.

The Center for the Study of Retired Athletes at the University of North Carolina works in close affiliation with the National Football League Players Association. Since 2001, the Center has been investigating a spectrum of physical and mental disabilities common to retired athletes. The research team will begin work in July 2008, with initial research results expected in 2010.

Since its founding in 1942 by the Sisters of Charity of Leavenworth, Saint John's Health Center has been providing the patients and families of Santa Monica, West Los Angeles and ocean communities with compassionate, advanced medical care. Saint John's provides a spectrum of treatment and diagnostic services with distinguished areas of excellence in cancer care, cardiac care, orthopedics and women's health. Saint John's Health Center is also dedicated to bringing to the community the most innovative advances in technology and patient care available in a healing environment.

Since 1981, the John Wayne name has been committed by the Wayne family to groundbreaking cancer research in memory of the much-loved actor who died of cancer. The John Wayne Cancer Institute has received worldwide acclaim for advances in understanding the disease, focusing on melanoma (skin cancer), breast, prostate, colon, pancreatic, lung and liver cancer, as well as lymphoma and leukemia. With its unique ability to rapidly turn scientific breakthroughs into innovative approaches to treatment and early detection, JWCI provides immediate hope to cancer patients from around the globe.
Contacts

Saint John's Health Center
Greg Harrison, 310/829-8010
858/472-5560 (cell)
gregory.harrison@stjohns.org


Monday, August 25, 2008

 

Mesothelioma Survival Rates Among Patients Taking New Treatment

LegalView Recounts the Results of a Recent Mesothelioma Study That Reported High Survival Rates Among Patients Taking New Treatment

LegalView reported the results of an Italian study to its mesothelioma blog readers; the results detailed a positive outcome and increased survival rate for elderly pleural mesothelioma victims. The study, recently published in a British medical journal, used a combination of two medicinal treatments commonly prescribed separately.

Denver, CO, August 16, 2008 -- LegalView, the most comprehensive legal resource available on the Web, recounted the results of an Italian study to its mesothelioma information blog readers. The study attempted to increase the survival rate of elderly pleural mesothelioma patients by combining two medications: Alimta (pemtrexed) and Paraplatin (carboplatin). The results of the study were released in a June issue of the British Journal of Cancer and the conclusions detailed the highly-effective treatments, which increased the survival rate among pleural mesothelioma patients 65 years of age or older.

Mesothelioma is an incurable cancer that is often attributed to the inhalation of asbestos fibers and dust containing tremolite. Asbestos is a known carcinogen, according to the Environmental Protection Agency (EPA), which is responsible for regulating the cleanup of the hazardous material. Asbestos was often prized for its ability to remain fire-resistant, while being produced cheaply, and served as a key ingredient in many products including insulation that was implemented into homes, apartment complexes, universities, schools, business offices and hospitals around the country. Individuals who suffer from mesothelioma cancer are advised to speak with a knowledgeable mesothelioma attorney in order to better educate themselves on the possibility for developing a mesothelioma lawsuit. Due to the extremely costly medical bills associated with increasing survival rate among mesothelioma cancer victims, developing litigation may result in monetary compensation to assist with those medical bills.

LegalView not only offers resources on the most recent mesothelioma news and clinical trials, but also offers information on a variety of other legal issues afflicting millions of Americans. Most recently, LegalView updated several of its pharmaceutical drug information portals with news on updates and recalls; some of the portals include Viapro, Ketek and the Zimmer Durom cup.

The development of the Viapro information portal occurred after the U.S. Food and Drug Administration (FDA) issued a press release on the recall of the drug because of contamination of a harmful chemical known as thiomethisosildenafil. The male sexual-enhancement prescription drug, manufactured by EG Labs, is used to treat erectile dysfunction (ED). The undeclared ingredient may be harmful to patients especially when interacting with nitrates found in other prescription drugs. The Viapro recall occurred because the drug may cause dangerously low levels of blood pressure among patients also taking nitroglycerin for diabetes, high blood pressure, high cholesterol or heart disease.

Ketek, which is an antibiotic used to treat upper respiratory infections such as pneumonia, bronchitis and sinusitis, had its warning labels increased recently due to the threat of liver disease among patients consuming the drug. To learn more about the Ketek side effects, visit
http://ketek.legalview.com/.

Also among the recently updated information portals is that of the Zimmer Durom cup. Zimmer Holdings has ceased production of its Durom cup because of complaints that the hip socket was failing among many patients. Although the company has ceased production of the hip socket, pending internal investigations into the potential failure, the hip socket has already been used in over 12,000 hip replacement procedures since its introduction to the market in 2006. Patients who may be at risk for the Durom cup failure should seek medical attention immediately to ensure no further damage occurs.

About LegalView:
LegalView.com is a public service brought to you by Legal WebTV Network, LLC, a Limited Liability Corporation created by a group of the nation's most highly respected law firms: Anapol Schwartz; Brent Coon and Associates; Burg Simpson; Cohen, Placitella and Roth; James F. Humphreys and Associates; Lopez McHugh; and Thornton and Naumes. For more information on the accomplishments and track records of LegalView.com's superior sponsoring law firms and to get in touch with LegalView attorneys, visit LegalView at www.LegalView.com/.

Contact Information
LegalView
Katie Kelley
720-771-3246
press-releases@legalview.com
www.legalview.com


Tuesday, August 19, 2008

 

Industry Makes Request to Decrease Asbestos Regulations

LegalView Offers Mesothelioma Blog Readers Details of Disconcerting Request to Decrease Asbestos Regulations from Industry

LegalView informed mesothelioma blog readers of an potentially troubling request by automotive, chemical and mining industries' paid researchers to "water down" asbestos regulations. The industry-hired scientists argued that asbestos is no longer as dangerous, even though several international health organizations have declared no safe level of the material.

Denver, CO - August 2, 2008 -- LegalView, the number one resource for everything and anything legal on the Internet, recently updated readers with the latest piece of mesothelioma information, relating to the request by paid researchers for the automotive, chemical and mining industries to decrease asbestos regulations. In a July 2008 summit in Washington D.C., the Environmental Protection Agency (EPA) met with the Office of Solid Waste and Emergency regarding the request. The industry researchers argued that asbestos fibers found in sand, taconite and other materials are less toxic than originally deemed in the 1980s when the regulations were created. However, the EPA along with the International Agency for Research on Cancer, the Occupational Safety and Health Administration (OSHA) and The World Health Organization (WHO) have all determined that no level of exposure to asbestos fibers is safe and the material as well as products using asbestos should be permanently banned.

Asbestos was mined for years and was frequently used in the construction industry for an array of products, most often insulation. However, it was determined that exposure to asbestos fibers causes a deadly form of lung cancer known as mesothelioma. Individuals who suffer from mesothelioma cancer should contact an experienced mesothelioma attorney to receive a legal consultation on the possibility of developing a personalized mesothelioma lawsuit. Because the cancer is fatal and no completely effective mesothelioma treatment exists to reduce the disease it may be important to develop litigation and potentially receive monetary compensation to pay for costly medical bills. Mesothelioma is a dormant condition that can take decades before symptoms reveal themselves, at which point, little can be done to improve the illness.

According to news reports, at the Washington D.C. summit, approximately 83 public health officials signed a 29-page report on the "science-for-hire" practice, which Dr. Michael Silverstein, who wrote the report, alleges is occurring on the part of automotive, chemical and mining industries. The report, opposing the request, urged the EPA to focus on public health rather than big industry and to avoid decreasing the asbestos regulations.

Learn more about this ongoing issue as well as other legal issues through LegalView.com. LegalView continues to maintain a comprehensive library of legal issues; issues that may be causing harm to millions of Americans each year. LegalView recently updated several of its issues to include detailed information and news. Some of the recently updated sites include information on the Zimmer Durom cup, the Ketek antibiotic and Avandia prescriptions.

The Durom cup, manufactured by Zimmer Holdings, is an artificial hip component that has been under fire by physicians who have said the device is failing their patients. Because of the alleged Zimmer Durom cup risks, the company has ceased manufacture of the hip socket. However, since production began in 2006, nearly 12,000 patients received the cup and may be affected by the failing hip socket and should contact a knowledgeable attorney for advice about the potential Durom cup recall.

Ketek is a pharmaceutical prescription antibiotic that is used to treat upper respiratory infections including pneumonia or bronchitis. Reports have tied the antibiotic with the possibility of severe liver damage among patients. Additional Ketek side effects may also be considered dangerous and those who report signs of yellowing skin or jaundice should consult a doctor immediately

The Avandia portal is continually being updated to provide the public with extensive research, scientific findings and experienced attorney links. Avandia is a prescription drug used to treat type 2 diabetes, which currently affects millions of individuals in the United States. Recent research, however, has found a disturbing link between the use of Avandia and an increase of heart disease as well as osteoporosis among patients. Individuals who feel they may have symptoms relating to heart disease or who have suffered from a bone fracture likely induced by the Avandia side effects, should speak with a medical expert immediately. Additionally, it is advisable to locate an experienced pharmaceutical law firm in case legal advice is necessary for an Avandia settlement.

About LegalView:
LegalView.com is a public service brought to you by Legal WebTV Network, LLC, a Limited Liability Corporation created by a group of the nation's most highly respected law firms: Anapol Schwartz; Brent Coon and Associates; Burg Simpson; Cohen, Placitella and Roth; James F. Humphreys and Associates; Lopez McHugh; and Thornton and Naumes. For more information on the accomplishments and track records of LegalView.com's superior sponsoring law firms and to get in touch with LegalView attorneys, visit LegalView at www.LegalView.com/.

CONTACT INFORMATION
Katie Kelley
LegalView
720-226-6613

Alan Haburchak
LegalView
720-226-6613


Wednesday, August 06, 2008

 

Predicted Increase in Female Mesothelioma Victims

LegalView Informs Mesothelioma Blog Readers of a Predicted Increase in Female Mesothelioma Victims

LegalView updated readers to an alarming prediction by researchers who said the number of female mesothelioma victims may increase within the next few years. Researchers said that asbestos in hair dryers that were previously unregulated may be the cause.

Denver, CO - July 21, 2008 -- LegalView, the most comprehensive legal resource on the Web, reported on its mesothelioma information blog a potential increase of mesothelioma cancer victims within the next few years, particularly among women, according to researchers. In 1979, the U.S. Consumer Product Safety Commission (CPSC) released information regarding 26 companies and manufacturers of hand-held hair dryers that had been made with asbestos. While the 26 companies had voluntarily taken action to correct the asbestos-containing hair dryers, individuals who had used the tainted hair dryers may be at risk for developing mesothelioma and should consider contacting a mesothelioma lawyer for information on the development of a potential mesothelioma lawsuit.

Mesothelioma is a deadly form of lung cancer that is caused through the inhalation of asbestos fibers. While asbestos was largely used in the construction industry, commonly within insulation, it has also been used in other products including hair dryers. While the hair dryers were corrected and became asbestos-free nearly 30 years ago it is common for mesothelioma to remain dormant for years and even decades, which is why researchers are concerned with a new group of individuals becoming afflicted by mesothelioma and symptoms becoming prevalent now. Researchers are also particularly concerned for women because women allegedly use hair dryers more than men. To learn more about developing litigation, contact a mesothelioma law firm or mesothelioma attorney to better understand the potential for developing an asbestos-related lawsuit and receiving monetary compensation for the costly bills usually associated with a mesothelioma cancer diagnosis.

In addition to information on mesothelioma, LegalView also offers details on a plethora of other legal issues afflicting millions of Americans each year. For example, readers can learn about the latest fluoroquinolones black box warning labeling. Fluoroquinolones are a group of antibiotics that have become increasingly at risk for severe side effects. Of the fluoroquinolones group, the most commonly prescribed drugs are Levaquin and Cipro. Levaquin, also known as levofloxacin, is manufactured by Ortho-McNeil and treats bacterial infections, specifically treating infections such as skin infections, chronic bacterial prostates, urinary tract infections, pneumonia, bronchitis and acute pyelonephritis caused by Escherichia coli (E. coli). The drug, which was released in 1996, has been the center of numerous clinical trials and studies because of the possible Levaquin side effects, which can include the most serious - Achilles tendon rupture - as well as jaundice, seizures, hallucinations, abdominal tenderness and limb numbness.

Similar to Levaquin is Cipro (ciprofloxacin) from Bayer A.G., which was approved for market use in 2000 and is used to treat bacterial infections similar to those treated by Levaquin. The Cipro risks are the same as Levaquin, which is an increased risk of tendonitis. Additionally, Cipro has other side effects that may also be harmful to patients. Some of the side effects include seizure, difficulty breathing, depression, suicidal thoughts, blacking out and hallucinations.

LegalView also has information on other controversial prescription drugs including Avandia. Avandia is a type 2 diabetes drug that has recently been linked to severe risks among patients. The Avandia dangers may include an increased risk of heart failure as well as a higher risk of developing early onset osteoporosis. Patients who may have developed either of these side effects while taking Avandia should speak with an experienced pharmaceutical lawyer to better understand the potential for developing a potential Avandia lawsuit.

About LegalView:
LegalView.com is a public service brought to you by Legal WebTV Network, LLC, a Limited Liability Corporation created by a group of the nation's most highly respected law firms: Anapol Schwartz; Brent Coon and Associates; Burg Simpson; Cohen, Placitella and Roth; James F. Humphreys and Associates; Lopez McHugh; and Thornton and Naumes. For more information on the accomplishments and track records of LegalView.com's superior sponsoring law firms and to get in touch with LegalView attorneys, visit LegalView at www.LegalView.com/.


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