">

Thursday, October 19, 2006

 

CancerWire Published, Pushes Products

 
The 19th Edition of CancerWire is Published

CancerWire, the free e-newsletter for cancer, has just released its 19th edition. This edition includes: 1) information on a company that sells cancer medications at cost; 2) cancer news: Liquid Cartilage Extract and Cancer, Breast Cancer and CAM, Vitamin C and Cancer, Carotenoid-Rich Vegetables & Stomach Cancer, Hormone Therapy and Ovarian Cancer Risk, and Paul Kraus Helps Mesothelioma Patients; 3) medicinal mushrooms and immune system; 4) and immune boosting and nutritional support products and services for patients and professionals.

(PRWEB) October 19, 2006 -- Those learning about cancer for themselves or a loved one who have not subscribed to CancerWire the free cancer e-newsletter, are urged to subscribe by sending an email to info(at)cancermonthly.com with the word “subscribe” in the subject line.

Each month, CancerWire covers the latest news on alternative and integrative cancer therapies, with interviews, book reviews, and articles. Here’s a summary of the October edition:

Pharmacy Resource – SmartChoiceDrugStore is selling cancer medications at cost. SCD is a fully licensed, United States pharmacy. Medications are only purchased directly from the manufacturer or the nation’s top wholesale company. Call 1-866-289-6337 for more information. http://www.smartchoicedrugstore.com/

News –Liquid Cartilage Extract and Cancer, Breast Cancer and CAM, Vitamin C and Cancer, Carotenoid-Rich Vegetables & Stomach Cancer, Hormone Therapy and Ovarian Cancer Risk, and Paul Kraus Helps Mesothelioma Patients.
Go to http://www.cancermonthly.com/cancerwire/october2006.html to read more…

A Review of Dr. Merrill Garnett's Provocative Book "First Pulse” – This is a fascinating personal account of the author’s 40 year quest for an effective cancer therapy. Dr. Garnett has created and tested nearly 20,000 different organo-metallic compounds culminating in a palladium/lipoic acid complex. The palladium/lipoic acid complex is now being tested by researchers and clinicians.
Go to http://www.cancermonthly.com/cancerwire/october2006.html to read more…

A Discussion About Medicinal Mushrooms – Mushrooms have long been valued as delicious and nutritional foods by many societies. In Asia, it has been recognized that certain edible and non-edible mushrooms can have profound health benefits. In fact, a limited number of highly purified compounds derived from certain medicinal mushrooms are now being used in Asia and the U.S.
Go to http://www.cancermonthly.com/cancerwire/october2006.html to read more…

Two sources of unique mushroom extracts are Reishi Essence and Birkdale Medicinals. You can learn more about Reishi Essence from their website http://www.reishiessence.com or call them at (310)750-5918. You can learn more about at Birkdale Medicinals from their website http://www.immuneassist247.com or call them at (248) 693-8211.
Go to http://www.cancermonthly.com/cancerwire/october2006.html to read more…

Products and Services for Patients & Professionals – Learn More About Immune Boosting Products and Nutritional Support from:
The Foundation for Advancement in Cancer Research (FACR) http://www.facr.org/
Douglas Laboratories http://www.douglaslabs.com
Get Healthy Again.com http://www.health-reports.com/cancer-conquest.html
Polyerga® Plus http://www.polyergaplus.com
Haelan Products http://www.haelan951.com


###

Press Contact: Michael Horwin
Company Name: CANCER MONTHLY
Email: email protected from spam bots
Phone: 919-570-8595
Website:
http://www.cancermonthly.com


Sunday, October 08, 2006

 

FDA Approves ZOLINZA for the Treatment of Cutaneous Manifestations

 
FDA Approves ZOLINZA for the Treatment of Cutaneous Manifestations in Patients with Cutaneous T-cell Lymphoma Who Have Tried and Failed Other Therapies

ZOLINZA is Merck's first anticancer treatment in decades to be approved by the FDA

Whitehouse Station, N.J. (PRWEB) October 8, 2006 -- Merck & Co., Inc. today announced that the Food and Drug Administration (FDA) has approved oral ZOLINZA (vorinostat) 400 mg once daily for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL), a form of non-Hodgkin's lymphoma, who have progressive, persistent or recurrent disease on or following two systemic therapies. Cutaneous T-cell lymphoma is a cancer of the T-cells, a type of white blood cell, which affects the skin.
   
ZOLINZA is a histone deacetylase (HDAC) inhibitor. Based on in vitro studies, ZOLINZA inhibits the enzymatic activity of HDAC1, HDAC2, HDAC3 (Class I) and HDAC 6 (class II) at nanomolar concentrations (IC50 less than 86 nM). In some cancer cells, excess amounts of the enzyme HDAC prevent the activation of genes that control normal cell activity. ZOLINZA is believed to decrease the activity of HDAC. Decreasing the activity of HDAC allows for the activation of genes that may help to slow or stop the growth of cancer cells. The exact mechanism of the anticancer effect of ZOLINZA has not been fully characterized.

“With today's FDA approval of ZOLINZA, there is now an effective new option in the fight against cutaneous manifestations of cutaneous T-cell lymphoma, specifically in patients who have tried and failed other cancer treatment options,” said Elise Olsen, M.D., director, CTCL Clinic & Research Center at Duke University Medical Center and lead investigator of one of the studies that led to the approval.

The approval is based on two open-label clinical studies in which cutaneous T-cell lymphoma patients with refractory CTCL were evaluated to determine their response rate to oral ZOLINZA. One study was a Phase IIb, single-arm pivotal clinical study and the other assessed several dosing regimens. In both studies, patients were treated until disease progression or intolerable toxicity.

In the open-label, single-arm, pivotal study, the median age of patients was 60 years. Fifty-one percent of the patients were male and 49 percent were female. Eighteen percent of patients had Stage IB or IIA CTCL and 82 percent of patients had Stage IIB and higher cutaneous T-cell lymphoma. The median number of prior systemic therapies was three. Extent of skin disease was quantitatively assessed by investigators using a modified Severity Weighted Assessment Tool (SWAT).

The overall objective response rate in this study was 29.7 percent (22 of 74, 95% CI 19.7 to 41.5%) in all patients treated with ZOLINZA. Objective response was defined as at least four weeks of either a complete response, defined as no evidence of disease, or partial response, defined as greater than 50% decrease in a skin assessment score compared to baseline.                                                                                                                                                                                                                                                                                                                                                                                    
Secondary endpoints in this study included: time to objective response, time-to-progression, and duration of objective response. In the study, the median time to response was less than two months (55 days) in all patients, however, in rare cases, it took up to six months for patients to achieve an objective response to ZOLINZA. The median duration of response was not reached since the majority of responses continued at the time of analysis, but was estimated to exceed six months in all patients. The median time to progression approached five months (148 days) in all patients, based on a criterion for tumor progression of a 25 percent increase in SWAT score from the nadir.

The safety of ZOLINZA was evaluated in 107 cutaneous T-cell lymphoma patients in two single-arm clinical studies in which 86 patients received ZOLINZA 400 mg once daily. The most common side effects, regardless of causality, included fatigue (52 percent), diarrhea (52 percent), nausea (41 percent), change in taste (28 percent), low platelet count (26 percent), anorexia (24 percent), weight decreased (21 percent), and muscle spasms (20 percent).
   
“It is very gratifying to have ZOLINZA approved by the FDA for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who have tried and failed other therapies. I am confident it will be an important new addition to treat patients with CTCL," said Paul Marks, MD, President Emeritus and Member of the Sloan-Kettering Institute. "ZOLINZA was developed in an academic collaboration between the chemistry group of Ronald Breslow at Columbia University and my cancer biology group at Memorial Sloan-Kettering.     It is exciting to have Merck as a partner in the clinical development and FDA approval of ZOLINZA.

Dosing and Administration
   
The recommended dose of ZOLINZA is 400 mg orally once daily with food. If the patient is intolerant to therapy, the dose may be reduced to 300 mg orally once daily with food. The dose may be further reduced to 300 mg once daily with food for five consecutive days each week.
   
Treatment with ZOLINZA may be continued as long as there is no evidence of progressive disease or unacceptable toxicity. ZOLINZA capsules should not be opened or crushed.

Important Safety Information About ZOLINZA
   
As pulmonary embolism and deep vein thrombosis have been reported as adverse reactions, physicians should be alert to the signs and symptoms of these events, particularly in patients with a prior history of thromboembolic events. Treatment with ZOLINZA can cause dose-related thrombocytopenia and anemia. If platelet counts and or hemoglobin are reduced during treatment with ZOLINZA, the dose should be modified or therapy discontinued. Gastrointestinal disturbances, including nausea, vomiting and diarrhea, have been reported and may require the use of antiemetic and antidiarrheal medications. Fluid and electrolytes should be replaced to prevent dehydration. Pre-existing nausea, vomiting, and diarrhea should be adequately controlled before beginning therapy with ZOLINZA.
   
Based on reports of dehydration as a serious drug-related adverse event in clinical trials, patients should be instructed to drink as least two liters a day of fluids for adequate hydration. Hyperclycemia has been observed in patients receiving ZOLINZA. Serum glucose should be monitored, especially in diabetic or potentially diabetic patients. Adjustment of diet and or therapy for increased glucose may be necessary. QTc prolongation has been observed. Monitor electrolytes and ECGs at baseline and periodically during treatment. Hypokalemia or hypomagnesemia should be corrected prior to administration of ZOLINZA.
   
The most common serious adverse events, regardless of causality, in the 86 CTCL patients in two clinical studies were pulmonary embolism reported in 4.7 percent (4/86) of patients, squamous cell carcinoma was reported in 3.5 percent (3/86) of patients and anemia was reported in 2.3 percent (2/86) of patients.
   
Prolongation of prothrombin time (PT) and International Normalized Ratio (INR) were observed in patients receiving ZOLINZA concomitantly with coumarin-derivative anticoagulants. Physicians should carefully monitor PT and INR in patients concurrently administered ZOLINZA and coumarin derivatives. Severe thrombocytopenia and gastrointestinal bleeding have been reported with concomitant use of ZOLINZA and other HDAC inhibitors (e.g., valproic acid). Monitor platelet count every two weeks for the first two months.
   
ZOLINZA was not evaluated in patients with hepatic impairment. As ZOLINZA is predominately eliminated through metabolisym, patients with hepatic impairment should be treated with caution.    

Availability and Access
ZOLINZA will be made accessible to patients through Merck’s Accessing Coverage Today (ACT) program. ACT is a three-part program specifically designed to assist patients in obtaining ZOLINZA, help with insurance reimbursement issues, and provide support for those qualified individuals lacking insurance coverage for ZOLINZA. Patients without insurance coverage may be eligible for Merck's Patient Assistance Program, which allows them to receive ZOLINZA free of charge. Merck is also contributing to co-pay assistance foundations that provide co-pay assistance to qualified individuals. To enroll in the ACT program, patients need to call 1-866-363-6379 once they receive a prescription for ZOLINZA.

About CTCL
Cutaneous T-cell lymphoma, a type of non-Hodgkin’s lymphoma, is a form of cancer in T-cells, a type of white blood cell. Normal T-cells function by regulating the body’s immune system in its job of fighting infections and other foreign antigens. In CTCL, the malignant T-cells are drawn to the skin, where some are deposited. Patients usually develop CTCL after age 50. CTCL affects 20,000 patients in the United States, with another 1,500 new cases reported each year.

About Merck Oncology
Merck Oncology focuses on all aspects of cancer care -- prevention, treatment, and supportive care. Through strong internal research capabilities, selective alliances and acquisitions, and enabling technologies such as the Molecular Profiling platform of Rosetta, Merck Oncology is looking to lead in the discovery, development and delivery of targeted anticancer therapies customized for patient subpopulations. Merck Oncology conducts research at sites in Boston, Seattle, West Point, Japan and Italy.

About Merck
Merck & Co., Inc. is a global research-driven pharmaceutical company dedicated to putting patients first. Established in 1891, Merck currently discovers, develops, manufactures and markets vaccines and medicines to address unmet medical needs. The company devotes extensive efforts to increase access to medicines through far-reaching programs that not only donate Merck medicines but help deliver them to the people who need them. Merck also publishes unbiased health information as a not-for-profit service. For more information, visit
http://www.merck.com.

Forward-Looking Statement
This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements are based on management’s current expectations and involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements may include statements regarding product development, product potential or financial performance. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or
otherwise. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Merck's business, particularly those mentioned in the cautionary statements in Item 1 of Merck's Form 10-K for the year ended Dec. 31, 2005, and in its periodic reports on Form 10-Q and Form 8-K, which the company incorporates by reference.

###

Press Contact: Janet Skidmore
Company Name: Merck & Co
Email: email protected from spam bots
Phone: 267 305-7715
Website:
http://www.zolinza.com/vorinostat/zolinza/consumer/index.jsp


Friday, October 06, 2006

 

Technology Adoption Panel Looking for New Members

I am currently a TAP Panelist and just found out they are looking for new members. You don't get paid directly, but you do get a chance to win quite a bit of money. This is not a scam of any kind.

So that the people you refer don't think you're involving them in a scam, here are some answers to commonly-asked questions about the TAP, along with a
link to the registration survey at the end:

Who are you people, anyway? In-Stat (a division of Reed Business Information) is a leading provider of technology market research and consulting.

What's a "Technology Adoption Panel"? The "TAP" is a dynamic, online panel of more than 16,000 technology users and decision makers interested in contributing their opinions and insights about technology usage and issues in the workplace and at home.

I often experience technical difficulties while operating my telephone and other common technologies. Are you sure you want me to join your panel? Yes! The fact that you operate common technologies makes you a technology user. We want to hear about your personal experiences with the technologies that you have used.

I'm a very, very busy person. What will you expect of me if I join the panel? As a member you'll be sent periodic email invitations to participate in quick (as in 5-minutes-or-less quick) online surveys. You will never be invited to take more than one survey a week, and you are under no obligation to take any of the surveys (although we would love to include your experiences, perceptions, and opinions in as many of our research efforts in which you're willing to participate.)

Let's cut to the chase - what do I get out of this deal? In addition to helping to shape trends and identify issues regarding the role of new technology in business and personal life today and in the future, you'll have access to the executive summaries of all of our surveys. You'll also be entered into a drawing for a $100 American Express Gift Check after each survey for which you qualify and will also be entered into our quarterly drawings for $2000.

Will you be selling my survey responses to my neighbors, co-workers and psychiatrists? To ensure information provided by members is kept completely confidential, all data we collect is reported in aggregate. We do not sell or rent the personal information of our panelists, nor will we ever try to sell our members anything.

You had me at hello - how do I sign up? Simply click on the following
link and take the registration survey (which should take you around 5 minutes to complete). If you become a member by the end of this month, we will automatically enter you into our next quarterly drawing of $2000 (held on or about December 31, 2006.)

Join The Technology Adoption Panel

Thank you again, and good luck in the drawing.

Sincerely,

Stephanie Pickering
Primary Research Project Manager
In-Stat
225 Wyman Street
Waltham, MA 02451

Thursday, October 05, 2006

 

Call A Mesothelioma Survivor

 
Mesothelioma Survivor Available for Teleconferences

Mesothelioma patients can speak with Paul Kraus who is perhaps the world’s longest living mesothelioma survivor. The next free teleconference is scheduled for Thursday, October 12, 2006. Sign-up form is available at: http://www.survivingmesothelioma.com/speak-to-paul-kraus.cfm All mesothelioma patients are invited to attend.

(PRWEB) October 5, 2006 -- Mesothelioma patients can now speak directly to Paul Kraus, who has survived mesothelioma for more than nine years since diagnosis.

In 1997, Paul Kraus was diagnosed with mesothelioma. Because his disease was widely spread, his doctors told him that they could not cure him and that he should start putting his affairs in order. Instead of giving up, he created his own path to healing. “Dr. Andrew Weil wrote that any illness can be conquered through radical lifestyle change because our bodies are made with powerful self-healing capacities. It was damn hard to make such radical changes, but I was determined to see them through. I realized that to do otherwise meant that my chances of surviving were greatly diminished,” Kraus explained.

Today, more than nine years after his “death sentence” diagnosis, Mr. Kraus is alive with a good quality of life. He has written a book about his healing journey "Surviving Mesothelioma and Other Cancers: A Patient's Guide." He also holds free bi-monthly teleconferences so that other mesothelioma patients can speak directly to him and ask questions. Mr. Kraus is not a doctor and does not provide medical advice, but as a patient he is able to share his own insights into how he has healed and managed his mesothelioma.

These teleconferences have been called “inspirational” and “fabulous” by past attendees.

The next free teleconference is scheduled for Thursday, October 12, 2006. Sign-up form is available at: http://www.survivingmesothelioma.com/speak-to-paul-kraus.cfm All mesothelioma patients and their loved ones are invited to attend.

###

Press Contact: Michael Horwin
Company Name: CANCER MONTHLY
Email: email protected from spam bots
Phone: 619-261-7922
Website:
http://www.survivingmesothelioma.com/


Health blogs Health Blogs